Home>Meet Our Medical Team>William F. Regine, MD, FACR, FACRO

William F. Regine, MD, FACR, FACRO

Education and Training

  • State University of New York at Albany, BS, 1983
  • State University of New York Health and Science Center at Syracuse, MD, 1987
  • Residency, Thomas Jefferson University Hospital, Radiation Oncology, 1991
  • Fellowship, Thomas Jefferson University and University of Florida Hospitals, Radiation Oncology-Head and Neck and Gastrointestinal Malignancies, 1992


Dr. Regine leads a department which has achieved a Top 5 national ranking in National Institutes of Health research funding. He is recognized nationally and internationally in the areas of gastrointestinal and central nervous system malignancies and in the use of stereotactic radiosurgery (SRS). As Executive Director of the Maryland Proton Treatment Center, he leads the first and most advanced facility of its kind in the Batlimore-Washington, DC region — providing nearly 2,000 cancer patients a year with precise, “pencil-beam” technology to treat solid tumors.

In this video, Dr. Regine talks about proton therapy and the Maryland Proton Treatment Center:

Dr. Regine has served as principal or co-principal Investigator in at least four National Cancer Institute (NCI)-sponsored cooperative group clinical trials. He is a member of the GI and Brain Tumor steering committees for the NCI sponsored national cooperative clinical trials group known as NRG Oncology, and is the recent chairman of the GI section of the National Oral Board examination for trainees in radiation oncology. Dr. Regine served as the principal investigator of a study evaluating adjuvant therapy in patients with pancreatic cancer, which defined a new standard of care. He also has been the principal investigator/study chairman for two institutional clinical trials that defined new standards of care for patients with brain metastases and malignant spinal cord compression. Dr. Regine is co-editor of Principles and Practices of Stereotactic Radiosurgery, the first comprehensive textbook of its kind. He is also co-inventor of the first of its kind treatment device completely dedicated to the stereotactic radiation treatment of early stage breast cancer, known as the GammaPod.

Research/Clinical Keywords

Pancreas/Gastrointestinal Cancers, Central Nervous System Malignancies, Brain Metastases/Tumors, Head and Neck Cancers, Sarcomas, Stereotactic Radiosurgery (SRS), Proton Treatment

Highlighted Publications

Lin J, Lin M, Hall A, Singh D, Regine WF. Comparison of Bolus Electron Conformal Therapy plans to Traditional Electron and Proton Therapy to Treat Melanoma in the Medial Canthus. Practical Radiation Oncology (2016) Issue 6, Pages: 105-109, March 2016.

Chang L, Moughan J, Crane C, Hoffman JP, Regine WF, Abrams RA, Safran H, Freedman G, Guha C, Abbruzzese JL, Li Donghui. RECQ1 A159C Polymorphism is Associated with Overall Survival of Patients with Resected Pancreatic Cancer: A Replication Study in RTOG 9704. Int. J. Radiation Oncology Biol.Phys., 94:(3), Pages 554-560, March 2016.

Chin LS, Regine WF. Editors. Principles and Practice of Stereotactic Radiosurgery, Second Edition, Springer Publishing, 2015.

Mattiucci G.C., Falconi M., Stiphout R., Alfieri S., Calvo F., Maidment III B., Miller R., Regine WF, Reni M., Sharma N., Genovesi D., Balducci M., Deodato F., Valentini V., Morganti A. Adjuvant Chemoradiation in pancreatic cancer: a pooled analysis in elderly (≥ 75 years) patients. Scopus, Anticancer Research, 35(6):, 3441-3446, June, 2015.

Chuong M, Mehta, MP, Langen K, Regine WF. Is Proton Beam Therapy Better Than Standard Radiation Therapy? Clinical Advances in Hematology & Oncology, Volume 12, Issue 12, Pages: 861-869, December 2014.

Mehta M, Langen K, Regine WF. Expanding the Horizons of Proton Beam Therapy. Invited editorial. The Cancer Letter, Issue 31 – August 1, 2014.

Regine WF, et. al. Fluorouracil vs Gemcitabine Chemotherapy Before and After Fluorouracil-based Chemoradiation Following Resection of Pancreatic Adenocarcinoma: A Randomized Controlled Trial. JAMA. 2008;299(9):1019-1026.

Patchell RA, Tibbs PA, Regine WF, et. al. Postoperative Radiotherapy in the Treatment of Single Metastases to the Brain: A Randomized Trial. JAMA 280(17): 1485-1489, 1998.

Patchell R, Tibbs P, Regine WF, et. al. Randomized Trial of Direct Decompressive Surgical Resection in the Treatment of Spinal Cord Compression caused by metastatic cancer. The Lancet 366: 643-648, 2005.

Dr. Regine’s research interests include the study and treatment of pancreas/gastrointestinal cancers, brain metastases/ tumors, sarcomas and head and neck cancers. He is also Nationally recognized for his expertise in Stereotactic Radiosurgery (SRS).

Gastrointestinal Malignancies, Pancreatic cancer, Central Nervous System malignancies, Brain metastases, Head and Neck cancers, Sarcomas, Stereotactic Body Radiation Therapy (SBRT), Stereotactic Radiosurgery (SBRT), Gamma Knife Radiosurgery and Proton Therapy.

  • Fellowship Award, American Cancer Society Clinical Oncology, 1991
  • National Department Rank of “Top 5” in NIH Funding, 2006
  • “Best Doctors in America”, 2002-2008
  • “Best Doctors in Baltimore,” Baltimore Magazine, 2007-2014, 2016
  • “Super Doctors” in Mid-Atlantic, Washington Post, 2010-2013
  • “Top 1% of Doctors,” U.S. News & World Report, 2011
  • Fellow, American College of Radiology, 2013
  • Lifetime Volunteer Service Award, American Board of Radiology, 2015
  • ASTRO Abstract/Presentation Selected Among “Best of ASTRO”, 2015
  • University of Maryland, Department of Radiation Oncology, “Never Be Afraid to Try”, Teacher of the Year Award, 2016
  • University of Maryland Baltimore Entrepreneur of the Year, 2016
  • Assistant Member, Department of Radiation Oncology, St. Jude Children’s Research Hospital, 1992-1994
  • Assistant Professor, Section of Radiation Oncology, University of Tennessee, 1992-1994 (Acting Clinical Chief, 1994)
  • Associate Director for Clinical Research, Markey Cancer Center, University of Kentucky, 1998-2000
  • Professor, Joint Appointment, Department of Radiation Medicine and Department of Neurosurgery, University of Kentucky, 2002
William F. Regine, MD - Maryland Proton Treatment Center