Clinical Trials at MPTC
We are dedicated to advancing scientific knowledge about the role of proton therapy in the treatment of cancer. Clinical trials allow us to discover new and more effective treatments that would improve cancer outcomes for everyone diagnosed with the disease. With more than 30 clinical trials ongoing at our center, we are hopeful that MPTC will play a vital role in the advancement of radiation oncology.
Every patient treated at MPTC has access to a clinical trial. Read on to learn more about the trials we have available:
- NCT02603341 / GCC 15100: Pragmatic Phase III Randomized Trial of Photon vs Proton Therapy for Patients with Non-Metastatic Breast Cancer: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial [Sponsor: U. Pennsylvania] PI: Mark V. Mishra, MD
- NCT01766297 / GCC 1570 PCG BRE007: Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer [Sponsor: PCG] PI: Elizabeth M. Nichols, MD
- GCC 1570 PCG BRE007: Phase II protocol of proton therapy for partial breast irradiation in early stage breast cancer [Sponsor: PCG] PI: Elizabeth M. Nichols, MD
- NCT04181684 / GCC 19140: Pilot Study of Laser Interstitial Thermal Therapy Followed by Hypofractionated Radiation Therapy for Treatment of Recurrent Gliomas [Sponsor: U. Maryland] PI: Mark V. Mishra, MD
- NCT04699773 / GCC20138: Laser Interstitial Thermal Therapy Followed by Hypofractionated Radiation Therapy for Treatment of Newly Diagnoses High-Grade Gliomas [Sponsor: U. Maryland] PI: Mark V. Mishra, MD
- NCT03180502 / NRG BN005: Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma [Sponsor: NRG Oncology] PI: Mark V. Mishra, MD
- EA3191: A Phase II Randomized Trial of Adjuvant Therapy with Pembrolizumab After Resection of Recurrent/Second Primary Head and Neck Squamous Cell Carcinoma with High Risk Features [Sponsor: National Cancer Institute (NCI)] PI: Dan P Zandberg
- NRG HN009: Randomized Phase II/III Trial of Radiation With High-Dose Cisplatin (100 mg/m2) Every Three Weeks Versus Radiation With Low-Dose Weekly Cisplatin (40 mg/m2) for Patients With Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck [Sponsor: NRG] PI: Matthew Ferris, MD
- RTOG 1216: Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer [Sponsor: National Cancer Institute (NCI)] PI: Matthew Ferris, MD
- NCT03186898 / NRG GI003: A Phase III Randomized Trial of Protons Versus Photons for Hepatocellular Carcinoma [Sponsor: NRG] PI: Jason Molitoris, MD, PhD
- NCT03801876 / NRG GI006: Phase III Randomized Trial of Proton Beam Therapy (PBT) Versus Intensity Modulated Photon Radiotherapy (IMRT) for the Treatment of Esophageal Cancer [Sponsor: NRG] PI: Jason Molitoris, MD, PhD
- GCC 1886: Phase I Study of Concurrent Nab-Paclitaxel + Gemcitabine with Hypofractionated, Ablative Proton Therapy for Locally Advanced Pancreatic Cancer [Sponsor: University of Maryland] PI: Jason Molitoris, MD, PhD
- NCT04527900/GCC 2073: The “Upproach” Approach: A Phase 2 Study of Upfront Intensity Modulated Proton Beam Therapy (IMPT) and Concurrent Chemotherapy for Post-Operative Treatment in Loco-regionally Advanced Endometrial Cancer [Sponsor: University of Maryland] PI: Pranshu Mohindra, MD, MBBS
- GCC 1669: Pediatric Proton Consortium Registry: Registry for pediatric patients treated with proton RT [Sponsor: Massachusetts General Hospital] PI: Young Kwok, MD
- GCC 2032: Phase 1 Feasibility Study of Strength Training with Androgen Deprivation and Proton Therapy for Intermediate and High Risk Prostate Cancer [Sponsor: University of Maryland] PI: Matthew Ferris, MD
- NRG GU009: Parallel Phase III Randomized Trials For High Risk Prostate Cancer Evaluating De-Intensification For Lower Genomic Risk and Intensification of Concurrent Therapy for Higher Genomic Risk with Radiation (Predict-RT*) *Prostate RNA Expression/Decipher To Individualize Concurrent Therapy with Radiation [Sponsor: NRG] PI: Zaker Rana, MD
If you’re interested in participating in a clinical trial, please call (410) 369-5351 to check on availability or speak with your physician during your consultation.
